Selected Publications
  

1. Xing, Y., Lee, C. (2006) Alternative splicing and RNA selection pressure -- evolutionary consequences for eukaryotic genomes. Nat. Rev. Genet. 7: 499-510.

2. Xing, Y., Yu, T., Wu, Y.N., Roy, M., Kim J., Lee, C. (2006) An expectation-maximization algorithm for probabilistic reconstructions of full-length isoforms from splice graphs. Nucleic Acids Res 34: 3150-3160.

3. Xing, Y Lee, C (2005) Assessing the application of Ka/Ks ratio test to alternatively spliced exons. Bioinformatics (Oxford, England) 21 (19): 3701-3.

4. Lee, C., Wang, Q. (2005) Bioinformatics analysis of alternative splicing Briefings in Bioinformatics 6: 23-33.

5. Xing, Y Lee, C (2005) Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences. Proceedings of the National Academy of Sciences of the United States of America. 102 (38): 13526-31.

6. Roy, M Xu, Q Lee, C (2005) Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms. Nucleic acids research. 33 (16): 5026-33.

7. Xing, Y Lee, CJ (2005) Protein Modularity of Alternatively Spliced Exons Is Associated with Tissue-Specific Regulation of Alternative Splicing. PLoS Genetics 1 (3): e34.

8. Resch, A Xing, Y Modrek, B Gorlick, M Riley, R Lee, C (2004) Assessing the impact of alternative splicing on domain interactions in the human proteome. Journal of proteome research. 3 (1): 76-83.

9. Xing, Y Resch, A Lee, C (2004) The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures. Genome research. 14 (3): 426-41.

10. Lee, C Atanelov, L Modrek, B Xing, Y (2003) ASAP: the Alternative Splicing Annotation Project. Nucleic acids research. 31 (1): 101-5.

11. Modrek, B., Lee, C. (2003) Alternative splicing in the human, mouse and rat genomes is associated with an increased frequency of exon creation and/or loss. Nature Genetics 34: 177-180.

12. Lee, CJ Irizarry, K (2003) Alternative splicing in the nervous system: an emerging source of diversity and regulation. Biological psychiatry. 54 (8): 771-6.

13. Xu, Q Lee, C (2003) Discovery of novel splice forms and functional analysis of cancer-specific alternative splicing in human expressed sequences. Nucleic acids research. 31 (19): 5635-43.

14. Modrek, B Lee, C (2002) A genomic view of alternative splicing. Nature genetics. 30 (1): 13-9.

15. Xu, Q Modrek, B Lee, C (2002) Genome-wide detection of tissue-specific alternative splicing in the human transcriptome. Nucleic acids research. 30 (17): 3754-66.

16. Modrek, B Resch, A Grasso, C Lee, C (2001) Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic acids research. 29 (13): 2850-9.